Antidepressant Potential of Albizzia lebbeck SLNs

Background

To assess in vivo antidepressant of Ethanolic extract of Albizzia lebbeck (L.) own their family Fabaceae the plant's primary constituents Triterpenes, glycosides, saponins, flavonoids, and indole alkaloids are the main components of Albizzia lebbeck (L.), a member of the Fabaceae family, which is used to evaluate the in vivo antidepressant properties of its ethanolic extract. Reports on the pharmacological effects of anti-inflammatory, antioxidant, cytotoxic, anti-genotoxic, sedative and antiepileptic, anti-convulsant, anti-helminthic, anti-microbial, anti-fungal, and antipyretic substances can be found in the literature review. It has been reported that Albizzia lebbeck has anti-epileptic properties. Thus,

Materials and Methods

The current study is intended to have antidepressant effects on test animals. The impact of an Alzzia lebbeck (L.) leaf ethanol extract on Swiss albino mice's depression: For 21 days in a row, Swiss albino mice were repeatedly exposed to moderate stress. For 21 days, various groups of stressed and unstressed mice received oral doses of imipramine (15 mg/kg) and EEAL (200 and 400 mg/kg). The Open Field Test (OFT) and the Tail Suspension Test (TST) were performed locomotory one hour after the mice were given oral doses of 200 or 400 mg/kg of EEAL&ASLNs to assess their inclination toward depressive-like behavior.

Results

After receiving EEAL (200 mg/kg), ASLNs (100, 200, 400 mg/kg), and imipramine (15 mg/kg) for 21 days, the immobility duration of both stressed and unstressed mice was significantly reduced. Both TST and OFT showed the previously mentioned effect. Albizzia lebbeck (L.) ethanol leaf extract dramatically raised catalase levels while lowering MDA levels. After being treated with EEAL (200 mg/kg) and ASLNs, the serotonin levels of both calm and nervous mice significantly increased compared to their vehicle-treated counterparts.

Conclusion

The ASLNs demonstrated potent antidepressant-like effects in both stressed and relaxed mice, possibly lowering oxidative stress.