Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 58 | Issue 1 | 2024 | pp. 131–138Open access
Design and Development of Anti-fungal Topical Gel Loaded with Solid Lipid Nanoparticles for Wound Healing
- 1,
- 2,
- 2,
- 3,
- 4,
- 2*,
- 5,
- 6,7,
- 8,
- 9,
- 10,
- 1
- 1 Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 2 Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagar, Karnataka, INDIA.
- 3 Department of Pharmaceutics, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, Vile Parle (W), Mumbai, Maharashtra, INDIA.
- 4 Department of Pharmacognosy, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet, Andhra Pradesh, INDIA.
- 5 Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 6 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 7 Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, Karnataka, INDIA.
- 8 Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 9 Department of Restorative dentistry and Endodontics, College of Dentistry, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 10 Department of Surgery, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: N. Raghavendra Naveen
Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagar, Karnataka, INDIA.
Email: raghavendra.naveen@gmail.com
Copyright: © 2024 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2024
- Received:
- Jun 22, 2023
- Accepted:
- Oct 22, 2023
- DOI:
- 10.5530/ijper.58.1.13
How to cite
Meravanige, G., B, R., Goudanavar, P., Rao, G. K., Devi, B. N., Naveen, N. R., Asif, A. H., Nagaraja, S. H., Islam, M. M., Sreenivasalu, P. K. P., Telsang, M., & Sreehari, K. S. D. (2024). Design and Development of Anti-fungal Topical Gel Loaded with Solid Lipid Nanoparticles for Wound Healing. Indian Journal of Pharmaceutical Education and Research, 58(1), 131–138. https://doi.org/10.5530/ijper.58.1.13
Abstract
Background: The topical administration of antifungal drugs by Solid Lipid Nanoparticles (SLNs) has enormous potential. This study aimed to develop a topical 5-flucytosine-loaded SLNs gel to improve the efficacy of the well-known antifungal drug in the treatment of wound healing. Materials and Methods: In order to create 5-flucytosine SLNs, a five-level, two-factor Central-composite design was used. Stearic acid and Poloxamer 407 concentrations of surfactants were chosen as independent factors, and particle size and %Entrapment Efficiency (%EE) were chosen as dependent variables. The produced 5-Flucytosine-SLNs were examined using SEM analysis, zeta potential, polydispersity index, and particle size measurements. Additionally, Carbopol 934 was used to incorporate the improved 5-Flucytosine-SLN formula into gel. Results: The outcomes demonstrated that 5-Flucytosine-SLNs had colloidal sizes with an essentially spherical shape and no aggregation. 5-Flucytosine-SLNs were discovered to have a particle size of 720.4 nm and an Entrapment Efficiency (EE) of 90.28%. The in vitro release, among other assessment criteria, was evaluated for the improved SLN gels. Conclusion: The study's conclusions imply that the topical gels made with 5-Flucytosine-loaded SLNs must be effective in the management of wound healing.
Keywords
Subject
Article metadata
| Title | Design and Development of Anti-fungal Topical Gel Loaded with Solid Lipid Nanoparticles for Wound Healing |
|---|---|
| Authors | Girish Meravanige; Ranjitha B; Prakash Goudanavar; GSN Koteswara Rao; B Nirmala Devi; N. Raghavendra Naveen; Afzal Haq Asif; Sree Harsha Nagaraja; Mohammed Monirul Islam; Pavan Kumar Pavagada Sreenivasalu; Mallikarjun Telsang; Krishna Swaroop Duddi Sreehari |
| Affiliations | Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagar, Karnataka, INDIA.; Department of Pharmaceutics, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, Vile Parle (W), Mumbai, Maharashtra, INDIA.; Department of Pharmacognosy, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet, Andhra Pradesh, INDIA.; Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, Karnataka, INDIA.; Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Restorative dentistry and Endodontics, College of Dentistry, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Surgery, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA. |
| Corresponding author | raghavendra.naveen@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 58, Issue 1 (2024) |
Also in this issue
- The Traditional Uses, Phytochemistry, and Pharmacological Effects of Clitoria ternatea: A Reviewpp. 1–14
- Enlightening Pharmacological Mechanisms of Cannabidiol in Epilepsy: A Comprehensive Review on their Neuroprotective Potentialpp. 15–20
- Nanostructured Lipid Carriers: A Potential Era of Drug Delivery Systemspp. 21–33
- Liposomal Cosmeceuticals as Skin Protectives and Curativespp. 34–44
- A Novel Approach on Micro Sponges Drug Delivery System: Method of Preparations, Application, and its Future Prospectivepp. 45–63