Electrometric Study on Nature and Stability of Co^II, Ni^II and Cu^II Complexes with 5-Sulfosalicylic Acid in DMSO-Water Mixtures

Background:

The bioavailability of an element and its toxicity based on its chemical species. According to IUPAC the concept of chemical speciation is defined as it is a form of an element according to its oxidation state, isotopic composition, or complex and molecular structure. The speciation studies are profoundly plays a major role in studying the nature of trace elements in a human organism. Speciation of an element has a noticeable impact on bioavailability, distribution and toxicity. These studies have vital role in medical and pharmaceutical sciences.

Materials and Methods:

The present investigation conducted by using pH meter, processing of data done by Gran titration. To obtain best-fit chemical models, a modelling strategy such as SCPHD is used and a computer program MINIQUAD 75 is also employed for the refinement of results.

Results:

In the present investigation we considered the effect of dielectric constants of Dimethyl sulfoxide (DMSO) on stability constants of Co^II, Ni” and Cu^II with 5-Sulfosalicylic acid (5-SSA) complexes. The formed binary complex species are ML, MLH and ML2 and obtained skewness values range from -0.15-0.71 for Co^II, -0.27-0.32 for Ni” and -0.41-0.32 for Cu^II describes the distribution curves are left skewed and right skewed. The peak of the distribution curves shows platykurtic and leptokurtic with regards to the obtained values ranging from 2.89-6.14.

Conclusion:

It is observed that there is a significant influence of co-solvent, Dimethyl Sulfoxide (DMSO)-water mixtures on the stability constants of metal-ligand complexes, also studied how some factors such as changes in concentrations of ligand, acid, base log F and volume of the solution have influence on the protonation constants.