Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 60 | Issue 1 | 2026 | pp. 150–162Open access
Design and Characterization of Camptothecin Loaded Colloidosomes for the Effective Treatment of Lung Cancer
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- 1 Department of Pharmaceutics, Sant Gajanan Maharaj College of Pharmacy, Mahagoan, Kolhapur, Maharashtra, INDIA.
- 2 Department of Pharmaceutics, KLEs College of Pharmacy, Nippani, Karnataka, INDIA.
- 3 Department of Pharmaceutics, Vasantidevi Patil Institute of Pharmacy, Kodoli, Kolhapur, Maharashtra, INDIA.
- 4 Department of Pharmacognosy and Phytochemistry, KLEs College of Pharmacy, JNMC Campus, Belagavi, Karnataka, INDIA.
- 5 Department of Pharmaceutics, KLEs College of Pharmacy, JNMC Campus, Belagavi, Karnataka, INDIA.
- 6 Department of Pharmaceutics, Ashaokrao Mane Institute of Pharmaceutical Sciences and Research, Save, Maharashtra, INDIA.
- 7 Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, INDIA.
- 8 Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Swapnil Harale
Department of Pharmaceutics, Sant Gajanan Maharaj College of Pharmacy, Mahagoan, Kolhapur, Maharashtra, INDIA.
Email: gsunil201288@gmail.com
Copyright: © 2026 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2026
- Received:
- May 8, 2025
- Accepted:
- Aug 14, 2025
- DOI:
- 10.5530/ijper.20260528
How to cite
Harale, S., Mirajakar, K., Galatage, S., Manjappa, A., Patil, M., Sutar, K., Katkar, R., Bhagwat, D., Potti, L., Trivedi, R., Kandukuri, G., Kumbhar, P., Bille, K., & Patil, A. (2026). Design and Characterization of Camptothecin Loaded Colloidosomes for the Effective Treatment of Lung Cancer. Indian Journal of Pharmaceutical Education and Research, 60(1), 150–162. https://doi.org/10.5530/ijper.20260528
Abstract
Background:
Among the various cancers, lung cancer is the second leading cause of mortality after the breast carcinoma. Camptothecin (CPT) has broad spectrum anticancer potential used in the effective management of cancer including lung cancer. However, the therapeutic applications of CPT in the clinics are restricted due to its poor water solubility, low bioavailability and severe toxicities. Therefore, current research work was aimed to develop, optimize and characterize colloidosomes for safe and efficient delivery of CPT against lung cancer.
Materials and Methods:
Colloidosomes were prepared by using oil-in-water emulsion-based method and optimized using 32 Factorial design using sodium alginate as emulsifier and calcium carbonate as stabilizer. The optimized CPT Colloidosomes were lyophilized using freeze dryer and characterized for morphology by Transmission Electron Microscope (TEM), crystallinity by X-ray Diffraction (XRD), in vitro release, in vitro cytotoxicity, apoptotic potential etc.
Results:
The batch S9 has displayed high % entrapment efficiency (95±1.49%) and less particle size (327±9 nm and PDI: 0.267±0.019); therefore, it is selected as optimized batch. Besides, colloidosomes exhibited zeta potential of -24.5±3.2 mV revealing better stability. Further, the surface morphology results confirmed the self-assembling nature of colloidosomes which are spherical in shape. Moreover, lyophilized CPT Colloidosomes displayed sustained and maximum release of CPT (98±4.5%) after 8hr in PBS (Phosphate buffer solution) pH 7.4. Furthermore, the colloidosomes demonstrated significantly (p<0.01) higher in vitro cytotoxic and apoptotic activity against lung cancer (A549) cells after 48 hr of incubation.
Conclusion:
Results obtained revealed the remarkable in vitro anticancer potential of CPT in the form of colloidosomes which can further alleviate the side effects caused by systemic therapy of CPT. However; further in vivo animal studies are required to establish its efficacy treatment of lung cancer.
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Article metadata
| Title | Design and Characterization of Camptothecin Loaded Colloidosomes for the Effective Treatment of Lung Cancer |
|---|---|
| Authors | Swapnil Harale; Kaivalya Mirajakar; Sunil Galatage; Arehalli Manjappa; Mrityunjaya Patil; Kishori Sutar; Rushikesh Katkar; Durgacharan Bhagwat; Lakshmanarao Potti; Rahul Trivedi; Gourisankar Kandukuri; Prajyot Kumbhar; Kranti Bille; Ankush Patil |
| Affiliations | Department of Pharmaceutics, Sant Gajanan Maharaj College of Pharmacy, Mahagoan, Kolhapur, Maharashtra, INDIA.; Department of Pharmaceutics, KLEs College of Pharmacy, Nippani, Karnataka, INDIA.; Department of Pharmaceutics, Vasantidevi Patil Institute of Pharmacy, Kodoli, Kolhapur, Maharashtra, INDIA.; Department of Pharmacognosy and Phytochemistry, KLEs College of Pharmacy, JNMC Campus, Belagavi, Karnataka, INDIA.; Department of Pharmaceutics, KLEs College of Pharmacy, JNMC Campus, Belagavi, Karnataka, INDIA.; Department of Pharmaceutics, Ashaokrao Mane Institute of Pharmaceutical Sciences and Research, Save, Maharashtra, INDIA.; Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, INDIA.; Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat, INDIA. |
| Corresponding author | gsunil201288@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 60, Issue 1 (2026) |
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