Review ArticleInternational Journal of Pharmaceutical InvestigationVol. 16 | Issue 2 | 2026 | pp. 517–522Open access
Metabolism of mRNA Therapeutics: Insights into Pharmacokinetics and Toxicology
- 1*,
- 1,
- 1,
- 2,
- 3,
- 1,
- 4
- 1 Department of Pharmaceutics, Vishwakarma University, School of Pharmacy, Pune, Maharashtra, INDIA.
- 2 Department of Mechanical Engineering, Pandit Deendayal Energy University, Gandhinagar, Gujarat, INDIA.
- 3 Department of Qualtiy Assurance, Pioneer Pharmacy College, Sayajipura, Vadodara, Gujarat, INDIA.
- 4 Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Waghodia, Vadodara, Gujarat, INDIA.
Published in International Journal of Pharmaceutical Investigation
Correspondence: Yogita Shinde
Department of Pharmaceutics, Vishwakarma University, School of Pharmacy, Pune, Maharashtra, INDIA.
Email: galandeyogita@gmail.com
Copyright: © 2026 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2026
- Received:
- Aug 9, 2025
- Accepted:
- Dec 14, 2025
- DOI:
- 10.5530/ijpi.20260539
How to cite
Shinde, Y., Sharma, T. P., Shaha, A., Chaudhari, R., Rajeghorpade, R., Talele, D., & Talele, C. (2026). Metabolism of mRNA Therapeutics: Insights into Pharmacokinetics and Toxicology. International Journal of Pharmaceutical Investigation, 16(2), 517–522. https://doi.org/10.5530/ijpi.20260539
Abstract
Messenger RNA (mRNA) therapies are a groundbreaking treatment for various conditions, including infectious diseases, cancer, and genetic disorders. This review examines the processing of mRNA therapeutics in the body, focusing on pharmacokinetics, cellular handling, and potential toxicity. It highlights the importance of delivery methods, immune responses, and mRNA stability for effective treatment. Additionally, it addresses challenges like unintended effects and long-term safety, while proposing strategies to enhance mRNA stability and reduce toxicity. Ultimately, it provides insights into how understanding mRNA metabolism can support the future development of these therapies.
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Article metadata
| Title | Metabolism of mRNA Therapeutics: Insights into Pharmacokinetics and Toxicology |
|---|---|
| Authors | Yogita Shinde; Tanishka Prakash Sharma; Archana Shaha; Rakesh Chaudhari; Rashmi Rajeghorpade; Dipali Talele; Chitrali Talele |
| Affiliations | Department of Pharmaceutics, Vishwakarma University, School of Pharmacy, Pune, Maharashtra, INDIA.; Department of Mechanical Engineering, Pandit Deendayal Energy University, Gandhinagar, Gujarat, INDIA.; Department of Qualtiy Assurance, Pioneer Pharmacy College, Sayajipura, Vadodara, Gujarat, INDIA.; Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Waghodia, Vadodara, Gujarat, INDIA. |
| Corresponding author | galandeyogita@gmail.com |
| Journal | International Journal of Pharmaceutical Investigation |
| Volume / Issue | Vol. 16, Issue 2 (2026) |
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