Original ArticleInternational Journal of Pharmaceutical InvestigationVol. 16 | Issue 2 | 2026 | pp. 702–707Open access
In vitro Antioxidant and Antiglycemic Effects of Malus domestica, Musa acuminata Colla, Mangifera indica, Citrus reticulata and Punica granatum Fruits Peel Extracts
- 1,
- 1,
- 2,
- 3,
- 3,
- 1*
- 1 Department of Pharmacology, Saveetha Medical College, SIMATS, Thandalam, Chennai, Tamil Nadu, INDIA.
- 2 Department of Anatomy, Saveetha Medical College, SIMATS, Thandalam, Chennai, Tamil Nadu, INDIA.
- 3 Department of Pharmacology, MVJ Medical College and Research Hospital, Bangalore, Karnataka, INDIA.
Published in International Journal of Pharmaceutical Investigation
Correspondence: Thirunavukkarasu Jayaraman
Department of Pharmacology, Saveetha Medical College, SIMATS, Thandalam, Chennai, Tamil Nadu, INDIA.
Email: thirunavukkarasu75@outlook.com
Copyright: © 2026 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2026
- Received:
- Aug 14, 2025
- Accepted:
- Dec 24, 2025
- DOI:
- 10.5530/ijpi.20260059
How to cite
Prasad, C. R., Umeza, B., Yuvaraj, M., Khan, A. K. A., Nayaka, S. R., & Jayaraman, T. (2026). In vitro Antioxidant and Antiglycemic Effects of Malus domestica, Musa acuminata Colla, Mangifera indica, Citrus reticulata and Punica granatum Fruits Peel Extracts. International Journal of Pharmaceutical Investigation, 16(2), 702–707. https://doi.org/10.5530/ijpi.20260059
Abstract
Objectives
This study aims to evaluate the anti-glycemic and antioxidant qualities of Malus domestica fruit (apple), Musa acuminata Colla fruit (banana), Mangifera indica fruit (mango), Citrus reticulata fruit (orange), and Punica granatum (pomegranate) fruit peels.
Materials and Methods
In this study we used DDPH assay as per standard protocols to test the anti-oxidant activity of different peel extract of this study. Antiglycemic activity was tested using glucose diffusion inhibition assay.
Results
According to the DDPH test, the antioxidant activity of various fruit peels was found to vary. Pomegranate showed the highest activity at 77%, followed by orange at 71%, and mango peel at 66%. Results showed that mango peel inhibited glucose diffusion by 37%, pomegranate by 35%, and orange by 30%.
Conclusion
According to these findings, the peels of pomegranates and mangoes have an abundance of chemicals that have antioxidant and anti-glycemic properties. The research backs up the idea that the usually wasted fruit peels can be a source of natural compounds that can help with type 2 diabetes and oxidative stress. This provides encouraging evidence that these waste products can play a part in the creation of phytopharmaceuticals and functional foods, all while contributing to more environmentally friendly methods of trash management.
Keywords
Subject
Article metadata
| Title | In vitro Antioxidant and Antiglycemic Effects of Malus domestica, Musa acuminata Colla, Mangifera indica, Citrus reticulata and Punica granatum Fruits Peel Extracts |
|---|---|
| Authors | C Reddy Prasad; Bibi Umeza; M Yuvaraj; A K Afzal Khan; Swapna R Nayaka; Thirunavukkarasu Jayaraman |
| Affiliations | Department of Pharmacology, Saveetha Medical College, SIMATS, Thandalam, Chennai, Tamil Nadu, INDIA.; Department of Anatomy, Saveetha Medical College, SIMATS, Thandalam, Chennai, Tamil Nadu, INDIA.; Department of Pharmacology, MVJ Medical College and Research Hospital, Bangalore, Karnataka, INDIA. |
| Corresponding author | thirunavukkarasu75@outlook.com |
| Journal | International Journal of Pharmaceutical Investigation |
| Volume / Issue | Vol. 16, Issue 2 (2026) |
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