Original ArticleInternational Journal of Pharmaceutical InvestigationVol. 16 | Issue 2 | 2026 | pp. 722–727Open access
Comparison of Dermatology Life Quality Index and Skindex-16 Questionnaires in Breast Cancer Patients with Radiation Dermatitis
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- 1 Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, INDIA.
- 2 Department of Radiation Oncology, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, INDIA.
- 3 Department of Community Medicine, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, INDIA.
- 4 Department of Pharmaceutical Chemistry, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, INDIA.
Published in International Journal of Pharmaceutical Investigation
Correspondence: Jayasutha Jayram
Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, INDIA.
Email: jayasuthaj@sriramachandra.edu.in
Copyright: © 2026 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2026
- Received:
- Aug 14, 2025
- Accepted:
- Dec 24, 2025
- DOI:
- 10.5530/ijpi.20260607
How to cite
Kuppusamy, R., Devaraj, K., Thiruvengadam, G., Kannan, N., Ibrahim, M. A. A., Venkatesh, S., Lakshmisundaram, R., Selvam, S., Jaisankar, R., Renuga, A. V. R., Jayram, J., & Kondaveeti, S. S. (2026). Comparison of Dermatology Life Quality Index and Skindex-16 Questionnaires in Breast Cancer Patients with Radiation Dermatitis. International Journal of Pharmaceutical Investigation, 16(2), 722–727. https://doi.org/10.5530/ijpi.20260607
Abstract
Background
Radiation Dermatitis (RD) is the most common adverse effect of radiation therapy among the cancer patients, which has the potential to lower patients' quality of life. This study aimed to assess the health-related Quality of Life (HRQOL) of breast cancer patients with radiation dermatitis using Dermatology Life Quality Index (DLQI) and Skindex-16 Questionnaires and to determine the more appropriate questionnaire to assess the breast cancer patients with radiation dermatitis.
Materials and Methods
A prospective one arm cross over study was conducted with 31 breast cancer patients. The HRQOL was assessed weekly during radiation therapy by using DLQI and Skindex-16 questionnaires and reliability of questionnaires were analyzed.
Results
The HRQOL of breast cancer patients with radiation dermatitis were affected on day 7, 14, 21 and 28 which was found to be improved after termination of radiation therapy (p<0.01). The reliability of DLQI questionnaire was found to be high (s=0.805) when compared with Skindex-16 questionnaire (s=0.781).
Conclusion
DLQI was the highly reliable instrument when compared to Skindex-16 for measuring health-related quality of life of breast cancer patient with radiation dermatitis. The shortness and ease of implementation of DLQI will aid the researcher and clinicians to choose the DLQI questionnaire for assessing the HRQOL of breast cancer patients with radiation dermatitis.
Keywords
Subject
Article metadata
| Title | Comparison of Dermatology Life Quality Index and Skindex-16 Questionnaires in Breast Cancer Patients with Radiation Dermatitis |
|---|---|
| Authors | Rohith Kuppusamy; Keerthika Devaraj; Gayathri Thiruvengadam; Nandhakumar Kannan; Mohamed Ashik Ahamed Ibrahim; Sriniga Venkatesh; Raman Lakshmisundaram; Sindhu Selvam; Ruthresh Jaisankar; Aswin Venkadesh Ramamoorthy Renuga; Jayasutha Jayram; Satish Srinivas Kondaveeti |
| Affiliations | Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, INDIA.; Department of Radiation Oncology, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, INDIA.; Department of Community Medicine, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, INDIA.; Department of Pharmaceutical Chemistry, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, INDIA. |
| Corresponding author | jayasuthaj@sriramachandra.edu.in |
| Journal | International Journal of Pharmaceutical Investigation |
| Volume / Issue | Vol. 16, Issue 2 (2026) |
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