Original ArticleInternational Journal of Pharmaceutical InvestigationVol. 16 | Issue 3 | 2026 | pp. 968–977Open access
Evaluation of Myostaal SB in Osteopenia Management through Bone Remineralization: A Proof-of-Concept, Open-Label, Single-Arm Study in Middle-Aged and Older Adults
- 1,2,
- 3,
- 4,
- 5,
- 3,
- 6*
- 1 Department of Swasthavritta and Yoga, D. Y. Patil deemed to be University School of Ayurveda, Nerul, Navi Mumbai, Maharashtra, INDIA.
- 2 Department of Swasthavritta and Yoga, All India Institute of Ayurveda, Goa, INDIA.
- 3 Department of Sanskrit Samhita & Siddhant, D. Y. Patil deemed to be University School of Ayurveda, Nerul, Navi Mumbai, Maharashtra, INDIA.
- 4 Medical Services, Solumiks Herbaceuticals Limited, 135, Nanubhai Desai Road, Khetwadi, Mumbai, Maharashtra, INDIA.
- 5 Clinical Research Associate, Shree Dhootapapeshwar Limited, 135, Nanubhai Desai Road, Khetwadi, Mumbai, Maharashtra, INDIA.
- 6 Department of Rasashastra and Bhaishajya Kalpana, D. Y. Patil deemed to be University School of Ayurveda, Nerul, Navi Mumbai, Maharashtra, INDIA.
Published in International Journal of Pharmaceutical Investigation
Correspondence: Vedvati Bhapkar
Department of Rasashastra and Bhaishajya Kalpana, D. Y. Patil deemed to be University School of Ayurveda, Nerul, Navi Mumbai, Maharashtra, INDIA.
Email: drvedvati@gmail.com
Copyright: © 2026 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2026
- Received:
- Dec 22, 2025
- Accepted:
- Apr 15, 2026
- DOI:
- 10.5530/ijpi.20260038
How to cite
Chitrakar, M., Harit, M. K., Chawda, M., Nalawade, M., Pawar, V., & Bhapkar, V. (2026). Evaluation of Myostaal SB in Osteopenia Management through Bone Remineralization: A Proof-of-Concept, Open-Label, Single-Arm Study in Middle-Aged and Older Adults. International Journal of Pharmaceutical Investigation, 16(3), 968–977. https://doi.org/10.5530/ijpi.20260038
Abstract
Background
Myostaal SB is a rational herbo-mineral Ayurveda formulation for management of Asthikshaya (~ osteopenia). It contains Kukkutandatvak Bhasma (Processed Hen-egg Shell), Asthisamhruta (Cissus quadrangularis), and Shatavari (Asparagus racemosus). Present proof-of-concept clinical study was planned to explore its efficacy in osteopenia management. The primary objective was to evaluate improvement of Bone Mineral Density (BMD) scores in DEXA scan. The effect on bone health biochemical markers viz., serum Alkaline Phosphatase, Parathyroid and Vitamin D were also assessed, along with clinical and quality of life improvement.
Materials and Methods
Total 35 adults of either sex aged, 40-75 years suffering from osteopenia with BMD T- score between -1 to -2.5 were allocated to intervention. All participants had a documented history of fractures likely resulting from low-impact trauma or injuries. Tab. Myostaal SB was given in a dose of one tablet thrice a day for 180 days. The baseline parameters, laboratory investigations were done as per the protocol. Data generated through clinical study were subjected to appropriate statistical tests.
Results
The results indicated significant BMD improvement in mean T-scores of AP spine and radius and marked improvement in femur and femur neck. Significant reduction in ALP and PTH; and marked improvement in Vitamin D levels were observed. Clinical improvement and improved quality of life were also noted. No adverse events were reported.
Conclusion
The positive role of Myostaal SB in bone remodeling was confirmed with improvement in bone strength and bone resorption markers. Thus, Myostaal SB Tablets can play a positive role in the management of osteopenia.
Keywords
Subject
Article metadata
| Title | Evaluation of Myostaal SB in Osteopenia Management through Bone Remineralization: A Proof-of-Concept, Open-Label, Single-Arm Study in Middle-Aged and Older Adults |
|---|---|
| Authors | Mrudul Chitrakar; Mahesh Kumar Harit; Mukesh Chawda; Megha Nalawade; Vinay Pawar; Vedvati Bhapkar |
| Affiliations | Department of Swasthavritta and Yoga, D. Y. Patil deemed to be University School of Ayurveda, Nerul, Navi Mumbai, Maharashtra, INDIA.; Department of Swasthavritta and Yoga, All India Institute of Ayurveda, Goa, INDIA.; Department of Sanskrit Samhita & Siddhant, D. Y. Patil deemed to be University School of Ayurveda, Nerul, Navi Mumbai, Maharashtra, INDIA.; Medical Services, Solumiks Herbaceuticals Limited, 135, Nanubhai Desai Road, Khetwadi, Mumbai, Maharashtra, INDIA.; Clinical Research Associate, Shree Dhootapapeshwar Limited, 135, Nanubhai Desai Road, Khetwadi, Mumbai, Maharashtra, INDIA.; Department of Rasashastra and Bhaishajya Kalpana, D. Y. Patil deemed to be University School of Ayurveda, Nerul, Navi Mumbai, Maharashtra, INDIA. |
| Corresponding author | drvedvati@gmail.com |
| Journal | International Journal of Pharmaceutical Investigation |
| Volume / Issue | Vol. 16, Issue 3 (2026) |
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