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Original ArtcileJournal of Young PharmacistsVol. 12 | Issue 2s | pp. s113–s116Open access
Development and Validation of Microbiological Analytical Method for Determination of Potency of Voriconazole Tablets
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- 1 Department of Pharmaceutical Analysis, G. Pulla Reddy College of Pharmacy, Hyderabad, Telangana, INDIA.
- 2 Department of Biotechnology, G. Pulla Reddy College of Pharmacy, Hyderabad, Telangana, INDIA.
Published in Journal of Young Pharmacists
Correspondence: Sana Fathima
Department of Pharmaceutical Analysis, G. Pulla Reddy College of Pharmacy, Hyderabad, Telangana, INDIA.
Email: fatimasana051@gmail.com
- Received:
- Mar 12, 2020
- Accepted:
- Jul 2, 2020
- DOI:
- 10.5530/jyp.2020.12s.58
How to cite
Sahitya, M., Fathima, S., Divya, A., Vaishali, K., NidhiSree, M., Reddy, C. S., Ramya, T. S., Rani, S., Padmavathi, Y., & Kiran, R. Development and Validation of Microbiological Analytical Method for Determination of Potency of Voriconazole Tablets. Journal of Young Pharmacists, 12(2s), s113–s116. https://doi.org/10.5530/jyp.2020.12s.58
Abstract
A new microbiological method was developed for analysis of voriconazole tablets using Candida albicans as test microorganism. Various media, species and conditions were used to optimize the diffusion test. A prospective validation of the system showed adequate linearity (0.995), accuracy (RSD<2%) and consistency (mean recovery= 101.77%). High performance liquid chromatography was selected as a tool of comparison for evaluating voriconazole. Results of both the microbiological and HPLC methods have been compared with the student t-test and the voriconazole content determined by both methods has shown strong correlation. The developed microbiological analytical method provides true indication of biological activity and can be used in dosage forms for routine quality control analysis of voriconazole.
Keywords
Subject
Article metadata
| Title | Development and Validation of Microbiological Analytical Method for Determination of Potency of Voriconazole Tablets |
|---|---|
| Authors | Mami Sahitya; Sana Fathima; Ancha Divya; Kyadari Vaishali; Meshkhana NidhiSree; Challoori Spandana Reddy; Toleti Sree Ramya; Sandhya Rani; Yenumula Padmavathi; Ravi Kiran |
| Affiliations | Department of Pharmaceutical Analysis, G. Pulla Reddy College of Pharmacy, Hyderabad, Telangana, INDIA.; Department of Biotechnology, G. Pulla Reddy College of Pharmacy, Hyderabad, Telangana, INDIA. |
| Corresponding author | fatimasana051@gmail.com |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 12, Issue 2s |
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