HPLC Based Metabolomic Fingerprint Profiling as A Comprehensive Quality Assessment Tool, Why Not for Standardization of Ayurvedic Herbs and Formulations?

A global resurgence and rampant increase in the usage of herbal medicines has led to malpractices in the absence of adequate regulatory control to meet the growing demand. To ensure quality and hence efficacy, of these drugs is the prime concern. The reason for poor regulatory control over herbal drugs is lack of adequate and accepted methods for evaluating them. In spite of technological advancement in analytical methods and instruments, standardization of herbal drugs is still an elusive goal. High Performance Liquid chromatography based metabolomic fingerprint profiling approach for different herbs and herbal formulations can be answer to this. HPLC based this approach is robust, precise, quantitative, easy to use, thus safeguarding that herbal medicine can be authenticated for their quality evaluation. In this review an introduction is given that why the quality evaluation of herbal medicine is important by means of HPLC based metabolomics. This approach includes extraction, chromatographic analysis and chemometric analysis to the produced chromatographic data. Various studies based on this approach are discussed that can be the torch light and helpful to keep the Legacy of intangible ayurvedic culture intact, that why and how this approach should be adopted.