Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 54 | Issue 1 | 2020 | pp. 46–54Open access
Spray Dried Amorphous Form of Simvastatin: Preparation and Evaluation of the Buccal Tablet
- 1,3*,
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- 4,
- 1,
- 1,
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- 1 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 2 Department of Pharmaceutics, PA College of Pharmacy, Mangalore, Karnataka, INDIA.
- 3 Department of Pharmaceutics, Vidya Siri College of Pharmacy, Bangalore, Karnataka, INDIA.
- 4 Department of Pharmaceutics, KLE University, Woman's College of Pharmacy, Belgaum, Karnataka, INDIA.
- 5 Department of Biotechnology and Food Technology, Durban University of Technology, Durban, SOUTH AFRICA.
- 6 Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, SAUDI ARABIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Nagaraja SreeHarsha
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutics, Vidya Siri College of Pharmacy, Bangalore, Karnataka, INDIA.
Email: sharsha@kfu.edu.sa
Copyright: © 2020 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2020
- Received:
- May 14, 2019
- Accepted:
- Nov 22, 2019
- DOI:
- 10.5530/ijper.54.1.6
How to cite
SreeHarsha, N., Hiremath, J. G., Sarudkar, S., Attimarad, M., Al-Dhubiab, B., Nair, A. B., Venugopala, K. N., & Asif, A. H. (2020). Spray Dried Amorphous Form of Simvastatin: Preparation and Evaluation of the Buccal Tablet. Indian Journal of Pharmaceutical Education and Research, 54(1), 46–54. https://doi.org/10.5530/ijper.54.1.6
Abstract
Background: The success of a drug primarily depends on its bioavailability. By enhancing the solubility and dissolution properties of drugs that are scarcely water soluble, significantly improves their bioavailability. Methods: This study was aimed to prepare a solid dispersion of the drug simvastatin that is a poorly water-soluble drug, through the spray drying technique. Solid dispersion carrier PVP, adsorbent Aerosil 200 and solvent dichloromethane were used to prepare solid dispersion. The pure simvastatin, solid dispersion and physical mixture were analyzed using FTIR, XRD and DSC studies. IR studies confirmed the possibility of hydrogen bonding in solid dispersion. Results: XRD and DSC studies revealed that the amorphous form of simvastatin was present in the solid dispersion. The spray dried form of simvastatin was formulated into a buccal tablet by using carbopol 934 and HPMC K4M as mucoadhesive polymers. The drug release from buccal tablets indicated that improvement in solubility, the rate of dissolution of poorly water-soluble drug simvastatin. Conclusion: The study shows that the tremendous potential of solid dispersions of simvastatin by using spray drying technique.
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Article metadata
| Title | Spray Dried Amorphous Form of Simvastatin: Preparation and Evaluation of the Buccal Tablet |
|---|---|
| Authors | Nagaraja SreeHarsha; Jagadeesh Gurupadayya Hiremath; Suhas Sarudkar; Mahesh Attimarad; Bandar Al-Dhubiab; Anroop Balachandran Nair; Katharigatta Narayanaswamy Venugopala; Afzal Haq Asif |
| Affiliations | Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutics, PA College of Pharmacy, Mangalore, Karnataka, INDIA.; Department of Pharmaceutics, Vidya Siri College of Pharmacy, Bangalore, Karnataka, INDIA.; Department of Pharmaceutics, KLE University, Woman's College of Pharmacy, Belgaum, Karnataka, INDIA.; Department of Biotechnology and Food Technology, Durban University of Technology, Durban, SOUTH AFRICA.; Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, SAUDI ARABIA. |
| Corresponding author | sharsha@kfu.edu.sa |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 54, Issue 1 (2020) |
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