Protein Phosphatase 2A Activation for the Treatment of Alzheimer Disease-Promises and Challenges

Mondal, Prasenjit; Samajdar, Saptarshi; Acharyya, Suman; Mondal, Sumanta

doi:10.5530/ijpi.13.4.089

Review ArticleInternational Journal of Pharmaceutical InvestigationVol. 13 | Issue 4 | pp. 711–720Open access

Protein Phosphatase 2A Activation for the Treatment of Alzheimer Disease-Promises and Challenges

¹,
¹^*,
²,
³

¹ Department of Pharmaceutical Technology, Brainware University, Ramkrishnapur Road, Kolkata, West Bengal, INDIA.
² Department of Pharmaceutical Chemistry, Netaji Subhas Chandra Bose Institute of Pharmacy, Tatla, Roypara, Chakdaha, Nadia, West Bengal, INDIA.
³ Department of Pharmaceutical Chemistry, GITAM School of Pharmacy, GITAM University, Gandhinagar, Rushikonda, Vishakhapatnam, Andhra Pradesh, INDIA.

Correspondence: Saptarshi Samajdar
Department of Pharmaceutical Technology, Brainware University, Ramkrishnapur Road, Kolkata, West Bengal, INDIA.
Email: saptarshisamajdar20@gmail.com

Received:: Mar 29, 2023
Accepted:: May 10, 2023
DOI:: 10.5530/ijpi.13.4.089

How to cite

Mondal, P., Samajdar, S., Acharyya, S., & Mondal, S. Protein Phosphatase 2A Activation for the Treatment of Alzheimer Disease-Promises and Challenges. International Journal of Pharmaceutical Investigation, 13(4), 711–720. https://doi.org/10.5530/ijpi.13.4.089

Abstract

Alzheimer's disease is a progressive brain condition. It is characterized by alterations in the brain that result in the deposition of certain proteins. The brain shrinks and finally dies as a result of Alzheimer's disease. Over the years there has been very concerned efforts to control Alzheimer's disease with strategies like vaccinations but all off them failed in phase three trial. This leads to exploration of new strategy like activation of Protein Phosphatase 2A (PP2A) to control the tau phosphorylation in Alzheimer’s. In this review, a comprehensive review regarding activation of PP2A using drugs like metformin, sphingosides, ceramides, folate and xylulose 5 phosphate, Sodium selenate, Adamantane derivatives, phenolic derivatives, Isoquinolones and Tetralones. Therefore, this approach can offer a fresh glimmer of hope for the treatment of Alzheimer's disease.

Keywords

Subject

Article metadata

Title	Protein Phosphatase 2A Activation for the Treatment of Alzheimer Disease-Promises and Challenges
Authors	Prasenjit Mondal; Saptarshi Samajdar; Suman Acharyya; Sumanta Mondal
Affiliations	Department of Pharmaceutical Technology, Brainware University, Ramkrishnapur Road, Kolkata, West Bengal, INDIA.; Department of Pharmaceutical Chemistry, Netaji Subhas Chandra Bose Institute of Pharmacy, Tatla, Roypara, Chakdaha, Nadia, West Bengal, INDIA.; Department of Pharmaceutical Chemistry, GITAM School of Pharmacy, GITAM University, Gandhinagar, Rushikonda, Vishakhapatnam, Andhra Pradesh, INDIA.
Corresponding author	saptarshisamajdar20@gmail.com
Journal	International Journal of Pharmaceutical Investigation
Volume / Issue	Vol. 13, Issue 4

Also in this issue

A Study of Nitrosamine Impurities and Regulations Governing their Presence in Drug Productspp. 680–687
Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn.: A Reviewpp. 688–697
Type3c Diabetes Mellituspp. 698–702
A Study on BioBetters: Various Aspects and Regulatory Approval Processpp. 703–710
An Overview of a Biomarker in Breast Cancerpp. 721–734

Readers Also Viewed

Original Article

AMR Curator-An Interactive Platform for Analysing AMR Literature Using NLP

Umesh Rani, Naval Singh, Deepshikha Kaushik

Aug 11, 2026

Short Communication

Epigenetic Mechanisms of Foetal Imprinting: Integrating Garbha-Sanskar with Prenatal Stress and Cognitive Development

Manoj Mahavir Khavate, Dipess Ramdas Chikane, Sanket Rajendra Vakte