Targeted Lipid Based Vesicles as Drug Delivery Systems in Cancer Treatment

Cancer is not a single disease, it is a multifaced malignant tumor, having ability to develop in any part of our body and it can spread to the distant regions with the high-end cell proliferation within short duration of time. As per WHO statistics in 2023, 1 in 6 deaths occurred globally caused by cancer. Out of the available treatments to treat cancer like surgery, radiotherapy, chemotherapy, stem cell, targeted drug therapy, most promising and lifelong treatment continued by the chemotherapy agents. These drugs continuous usage may leads to the Multi Drug Resistance (MDR) and toxic effects. Application of nano therapeutical treatment with lipid vesicular systems may provide the less toxic effects, increased permeation into tumor cells, avoid the MDR effect. Lipid vesicular systems like liposomes, ethosomes and transferosomes are some of the leading drug delivery systems. Modification on the surface of the lipid layer can change the drug pharmacokinetic properties to achieve the maximum bioavailability and reduce the risk of toxicity. Plant based drugs delivery through the lipid vesicles is the majorly concerned to benefit the cancer patient with the improved nutritional support and less toxic nature of chemical compounds.