An Insight into Polymeric Micelles Preparation Methods and Applications as Drug Delivery Approach: A Review

Polymeric micelles which are formed by the self-assembly of amphiphilic copolymers, are distinguished among the other forms of nanostructured carriers due to their restricted size distribution, conformation, and surface features that promote their accumulation in the tumor region. Their distinctive architecture enables them to dissolve hydrophobic medications, extends their circulation half-life, and ultimately results in improved therapeutic effectiveness. Their synthesis process is contingent upon the physicochemical properties of the block copolymers, which subsequently have a substantial impact on the efficacy of drug encapsulation. Owing to the increasing prevalence of compounds with solubility problems, the pharmaceutical industry is currently faced with a significant challenge in improving the solubility of medications. This paper delves into the basics of polymeric micelles by reviewing copolymers, technique of manufacture, and potential uses of polymeric micelles.